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KMID : 0043320060290121102
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Archives of Pharmacal Research
2006 Volume.29 No. 12 p.1102 ~ p.1108
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Anti-inflammatory Activity of Flavonoids from Populus davidiana
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Zhang XinFeng
Hung Tran Manh
Phuong Phuong Thien
Ngoc Tran Minh
Min Byung-Sun
Song Kyung-Sik
Seong Yeon-Hee
Bae Ki-Hwan
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Abstract
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An in vitro bioassay-guide revealed that the methanol (MeOH) extract of the stem bark of Populus davidiana showed considerable inhibitory activity against cyclooxygenase (COX-1, COX-2). Continuous phytochemical study of the MeOH extract of this plant led to the isolation of ten flavonoids; sakuranetin (1), rhamnocitrin (2), 7-O-methylaromadendrin (3), naringenin (4), eriodictyol (5), aromadendrin (6), kaempferol (7), neosakuranin (8), sakuranin (9) and sakurenetin-5,4’-di--D-glucopyranoside (10). Their structures were identified on the basis of their physicochemical and spectroscopic analyses. The isolated compounds, 1-10, were tested for their inhibitory activities against COX-1 and COX-2. Compound 7 was found to have potent inhibitory effect on COX-1 and a moderate effect on COX-2, meanwhile, compounds 1-6 showed moderate inhibition against COX-1 only. Moreover, compounds 5-8 exhibited suppressive effects on xanthine oxidase (XO). These results may explain, in part, the traditional uses of P. davidiana in ethnomedicine.
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KEYWORD
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Populus davidiana, Flavonoids, Anti-inflammatory, Cyclooxygenase, Xanthine oxidase
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